Job Description
Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more careers.bms.com/working-with-us . The Protein Homeostasis Thematic Research Center (PH TRC) at Bristol Myers Squibb is a premier oncology research engine focused on delivering transformative therapeutics to patients with hematologic malignancies and solid tumors. The TRC is built on BMS's world-class expertise in targeted protein degradation (TPD) and induced proximity technologies, leveraging these paradigm-shifting modalities to attack previously undruggable oncogenic targets and overcome mechanisms of resistance to existing cancer therapies. Our work spans the full arc of discovery from target identification and biological validation to the advancement of first-in-class degraders and molecular glues into clinical development. Position Summary The Discovery Biology Department within the PH TRC is seeking an exceptionally talented and driven Associate Director with a strong and proven track record in drug discovery within the TPD and induced proximity space, combined with deep expertise in cancer disease biology , particularly in oncology and/or hematological malignancies. This is a pivotal scientific leadership role for a candidate who brings both a rigorous mechanistic understanding of protein degradation biology and an intimate knowledge of the molecular and cellular underpinnings of cancer. The successful candidate will be a recognized expert in their field, capable of translating deep disease biology insights into compelling target hypotheses and advancing novel degrader programs from concept to preclinical proof-of-concept. You will lead a team of discovery biologists, partner closely with medicinal chemistry, structural biology, and translational teams, and serve as a key scientific voice in shaping the TPD pipeline strategy at BMS. Position Responsibilities In the role as an Associate Director within Protein Homeostasis Discovery Biology, the ideal candidate Leadership & Strategy Lead highly complex , high-impact TPD and induced proximity drug discovery programs, exercising significant scientific autonomy in defining objectives , prioritizing targets, and driving portfolio decisions. Direct cross-functional project teams in the design, execution, and interpretation of preclinical research programs, with a clear emphasis on oncology and hematologic malignancy indications. Develop and champion department strategy for target identification and validation, mechanism-of-action ( MoA ) characterization, and disease positioning , with a particular focus on leveraging induced proximity biology to address unmet medical need in cancer. Drive go/no-go decision-making at key program milestones and ensure optimal resource allocation to advance the most promising therapeutic programs. Serve as a key scientific thought leader within the TRC, contributing to both near-term program execution and long-term portfolio vision. Scientific Excellence Apply deep knowledge of TPD modalities (including molecular glues, bifunctional degraders, and next-generation induced proximity platforms) to guide target selection and therapeutic hypothesis generation in oncology and hematology. Leverage a thorough understanding of cancer disease biology , including oncogenic drivers, tumor microenvironment, resistance mechanisms, and patient stratification , to inform biologically differentiated program strategies. Oversee the development and optimization of advanced cell-based and molecular assays supporting drug discovery and translational research, including novel protein degrader characterization, E3 ubiquitin ligase engagement, ternary complex biology, and 3D/organoid tumor models reflective of hematologic and solid tumor disease contexts. Guide mechanistic studies and target validation experiments using state-of-the-art technologies (e.g., CRISPR/Cas9, inducible shRNA, lentiviral systems, proteomics, functional and biochemical assays).<