Job Description
Description Job Description The researcher will work in the laboratory of Hanna Irie and will be engaged in translational breast cancer research projects focused on regulators of growth, survival and drug resistance, as well as the tumor microenvironment. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breast cancers, particularly triple negative breast cancers, resist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the growth and metastases of triple negative breast cancers. The researcher will utilize patient-derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists. The researcher will also study how the immune microenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experiments, be responsible for accurate record keeping and contribute to overall maintenance of the laboratory. The goals are to develop and validate novel therapeutics targeting novel oncogenes in breast cancer models. Responsibilities Conducts routine and standardized experiments using appropriate research techniques specific to subject matter of the research project. Analyzes and assists in interpreting moderately complex results. Analyzes and assists in interpreting laboratory results. Performs assays to support research studies. Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies. Logs and tests samples; prepares and submits laboratory materials and specimens for shipment. Assists in new and unexpected research experiments and techniques. Assists in the collection, analysis and review of experimental data for publication and presentation. Performs other related duties Technical Duties Include Cell culture Western Blot Cell viability assays qPCR DNA preparation (bacterial transformation, DNA extraction, transfection) Lentivirus production Mouse handling-tumor cell injections, mouse surgeries, IVIS imaging Flow cytometry Organoid development and culture Microscopy Lab record keeping Contribute to laboratory maintenance Qualifications Bachelors or Masters degree in science or related field required No experience required. One year of research experience preferred. Background in cell biology/models, genetics, molecular biology, biochemistry, or immunology strongly preferred Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) strongly preferred Employer Description Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About The Mount Sinai Health System Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; d