Job Description
Site Name: USA - Massachusetts - Cambridge Posted Date: Mar 25 2026 At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more Our approach to R&D The Protein Biochemistry team at the GSK Vaccines R&D Center in Cambridge, MA is seeking an enthusiastic and highly motivated Protein Biochemist to join the team supporting vaccine and infectious disease-related initiatives. As a Principal Scientist, you will provide deep subject-matter expertise and hands-on leadership in high-throughput protein expression, purification, and biochemical/biophysical characterization, while shaping technical strategy, mentoring scientists, and influencing project direction at the portfolio level. This role requires close collaboration with cross-functional partners across disciplines, sites, and geographies to ensure protein reagents, data, and workflows are aligned with program goals and timelines. You will be expected to use and maintain a scientifically current, state-of-the-art laboratory environment, introduce new methods and protocols related to your area of expertise, and drive improvements in throughput and reproducibility. You will help identify opportunities for automated or semi-automated solutions, contribute to workflow design and method development, and ensure experimental data and metadata are captured in a structured, reusable way. You will perform complex data interpretation tasks and make effective decisions that influence project direction. Your critical thinking skills will be crucial. You will need to anticipate problems, proactively seek solutions, and use your scientific expertise to solve project-related problems. You will be expected to operate with a high degree of scientific independence, proactively identify and address technical risks, and introduce innovative approaches that elevate the performance, scalability, and impact of protein biochemistry workflows across the organization, including identifying opportunities to increase throughput and reproducibility and driving fit-for-purpose solutions from prototype to routine use. Your multicultural responsibilities will also be part of the role. You will need to interact with scientists based in other centers or countries, ensuring that you can access the most up-to-date knowledge and capabilities to efficiently fulfill your missions. Key Responsibilities: Design, optimize, and execute scalable, high‑throughput protein expression strategies across multiple host systems (including bacterial, mammalian, and insect platforms) to support vaccine discovery and development programs. Develop, standardize, and refine robust protein purification pipelines using chromatographic techniques such as affinity, ion exchange, and size exclusion chromatography, with a focus on reproducibility, efficiency, and pipeline reuse across projects. Implement high‑throughput and parallelized expression and purification workflows (e.g., plate-based approaches, automated chromatography where available) to rapidly evaluate constructs, optimize conditions, and enable timely delivery of high‑quality protein reagents to downstream teams. Identify and implement automation or semi‑automation opportunities across protein production and characterization (e.g., plate-based workflows, liquid handling where available, automated chromatography), supporting method development, robustness, and adoption while keeping scientific goals, data quality, and timelines in focus. Perform high‑throughput biochemical and biophysical characterization of purified proteins to assess purity, homogeneity, stability, and functionality, enabling data‑driven decisions on construct and workflow progression. Deliver consistent, well‑characterized protein reagents to support biophysical, structural biology, and in vivo studies, ensuring seamless integration with downstream experimental pipelines. Manage and interpret complex experimental datasets generated across expression, purification, and characterization workflows, and translate results into clear scientific conclusions that guide project direction. Introduce and implement new methods, protocols, and workflow improvements to enhance throughput, data quality, and operation