Job Description
Job Summary Summary of Key Responsibilities Hands-on lab support and process development for the chemical synthesis and downstream processing of oligonucleotide-based drug substance Synthesis of oligonucleotides up to 11 mmol scale Downstream processing of oligonucleotides including prep-HPLC, Ultrafiltration, annealing, concentration and Lyophilization In process analytical testing including AX-HPLC, IPRP-HPLC, LCMS, UV-vis Technical support for optimization of contract manufacturing processes Qualifications BS in Chemistry with 3+ years lab experience, preferably in an industrial setting. Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred. Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus. Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance. Good communication skills are a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.