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Senior Director, Project & Portfolio Management

insitro
FULL_TIME Remote ยท US South San Francisco, CA, US Posted: 2026-05-11 Until: 2026-06-10
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Job Description
The Opportunity The unprecedented convergence of multi-modal data, advanced disease modeling, and computational power is revolutionizing drug discovery. Insitro is harnessing this moment to redefine how medicines are developed for complex diseases. Our AI/ML-enabled platforms integrate and scale data to rapidly discover novel biological insights to redefine complex diseases and identify new targets and drugs. To enable this vision we are seeking a Senior Director of Project & Portfolio Management (PPM) who will build an AI-forward PPM organization that will partner with Therapeutic Area, Operations, Clinical and Business Development teams to discover and advance a high-value portfolio of exciting drug candidates into the clinic for neurological, ophthalmological and metabolic indications. Reporting into the CSO, you and your staff will partner with project team leaders in developing rightsized project strategies and create successful team environments to foster high performance and rapid advancement. You will develop and execute high quality integrated project plans with clear timelines spanning research, discovery, clinical development, software engineering, and data science/machine learning. As the leader of PPM you will partner with Compute, Operations and Finance colleagues in establishing agentic AI project management, decision and resource allocation tools and methodologies across our portfolio to support critical initiatives. This role will be hybrid, coming onsite to our South San Francisco headquarters with three days per week in the office. About You BS degree required in a life science field, MS or PhD preferred Minimum of 15 years of experience in biotech/pharmaceutical industry in the R&D and clinical development space, including 8+ years in project/portfolio leadership leading cross-functional matrix teams Extensive knowledge of the drug development process and deliver