Senior Medical Director, US Medical Affairs - TTR

Overview The Senior Medical Director, US Medical Affairs – TTR is accountable for leading the end-to-end US evidence generation strategy and execution in close partnership with Global Medical Affairs. This role drives the development of high-impact, non-promotional evidence to support clinical understanding, inform treatment decisions, and improve patient outcomes in transthyretin (TTR) amyloidosis. This individual will oversee US-based Investigator-Sponsored Studies (IIS/IIT), real-world evidence (RWE) initiatives, and serve as the US medical lead for publications, ensuring strong US input and execution within the global publications framework. The role includes direct management of an Associate Director and leadership across key enterprise evidence initiatives, including VEST and Health Systems evidence generation. Key Responsibilities End-to-End US Evidence Generation Leadership Own and lead the end-to-end US evidence generation strategy and execution, aligned with global medical and enterprise priorities Identify and prioritize US-specific evidence gaps and translate them into actionable study plans Drive development and execution of RWE, observational studies, registries, and database analyses (e.g., EHR, claims) Ensure seamless execution across the study lifecycle: concept development, protocol design, governance, execution, analysis, and dissemination Deliver high-quality, timely, and impactful evidence to support clinical practice and patient outcomes Health Systems Evidence Generation Leadership Serve as the US medical lead for Health Systems evidence generation strategy and execution Develop and advance evidence to demonstrate value in real-world clinical practice, including outcomes, healthcare utilization, and system-level impact Partner cross-functionally (e.g., HEOR, Market Access, Commercial, Global Medical) to align on priorities and maximize evidence impact Ensure integration of health systems evidence into broader US and global evidence strategies Investigator-Sponsored Studies (IIS/IIT) Oversight Provide strategic and scientific oversight of the US IIS/IIT portfolio Lead evaluation, prioritization, and governance of IIS proposals aligned with medical strategy Partner with investigators to shape robust, hypothesis-driven research Ensure compliance with internal policies, regulatory requirements, and ethical standards Publications (US Medical Lead) Serve as the US Medical Affairs lead for publications, ensuring strong US input into global publication strategy Partner with Global Medical Affairs to align on publication priorities, timelines, and execution Lead execution of US-led publications (abstracts, posters, manuscripts) in alignment with global plans Provide medical review to ensure scientific accuracy, relevance, and compliance Collaborate cross-functionally to ensure appropriate integration of clinical, RWE, and HEOR data VEST Leadership Serve as the primary US Medical lead to the VEST team, representing US medical priorities and ensuring alignment with enterprise evidence strategy Provide strategic input into VEST initiatives and ensure execution of US evidence components Act as a key connector between US Medical and cross-functional stakeholders involved in VEST People Leadership Directly manage and develop one Associate Director Provide clear direction, prioritization, and coaching to ensure high performance and professional growth Foster a culture of accountability, collaboration, and scientific excellence Cross-Functional Leadership Serve as a key medical partner across US and Global Medical Affairs, Clinical Development, HEOR, Market Access, and Commercial teams Translate complex data into clear, actionable insights for internal stakeholders Support field medical teams with evidence strategy and emerging insights Contribute to lifecycle management and differentiation through evidence generation External Engagement Build and maintain relationships with key opinion leaders (KOLs), academic institutions, and research networks Support strategic research collaborations aligned with US evidence priorities Represent the organization at scientific meetings and investigator interactions Qualifications Education & Experience MD, PharmD, or PhD in a relevant scientific or clinical discipline 8–12+ years of experience in Medical Affairs, Clinical Development, or related functions Demonstrated experience leading evidence generation (RWE, IIS/IIT) and supporting publications Prior people management experience preferred Experien