Job Description
The Position A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward. Key Responsibilities Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties. Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development. Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads. Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biolo